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Klin Monbl Augenheilkd 2023; 240(07): 887-890
DOI: 10.1055/a-1838-5027
Kasuistik

Choroidal Manifestation of Smoldering Myeloma: Case Report

Intraokuläre Manifestation eines Smoldering Multiplen Myeloms: Fallpräsentation
Ekaterina Sokolenko 
1   Department of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Patricia Johansson
2   Institute of Cell Biology (Cancer Research), Faculty of Medicine, University of Duisburg-Essen, Essen, Germany
,
Saskia Ting
3   Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Nikolaos E. Bechrakis
1   Department of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
,
Miltiadis Fiorentzis 
1   Department of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Abstract

This case illustrates clinical, histopathological, immunohistochemical, and molecular pathological diagnostic testing of smoldering myeloma with atypical ophthalmic manifestations. In our case, the choroidal lesion presented as a solitary manifestation of a systemic disease. Choroidal lesions of monoclonal plasma cells are extremely rare and should be included in the differential diagnosis of amelanotic choroidal lesions, even if the histopathological examination of the primary lesion is not informative. Clinical course, immunohistochemistry, and molecular pathology are essential components of the diagnostic pathway.

Zusammenfassung

Dieser Fall schildert klinische, histopathologische, immunhistochemische und molekulare pathologische Diagnoseverfahren beim Smoldering Myelom mit einem atypischen ophthalmologischen Erscheinungsbild. In unserem Fall war die Aderhautläsion die einzige Manifestation einer systemischen Erkrankung. Aderhautläsionen monoklonaler Plasmazellen sind extrem selten und sollten bei der Differenzialdiagnose amelanotischer Aderhautläsionen berücksichtigt werden, selbst wenn eine histopathologische Untersuchung der primären Läsion keinen Aufschluss liefert. Der klinische Verlauf, die Immunhistochemie sowie die molekulare Pathologie sind essenzielle Komponenten des diagnostischen Verlaufs.

Key words

ocular oncology - smoldering myeloma - ophthalmic manifestations of multiple myeloma

Schlüsselwörter

Ophthalmoonkologie - Smoldering Myelom - okuläre Manifestation eines Multiplen Myeloms


Publication History

Received: 10 July 2021

Accepted: 07 April 2022

Article published online:
28 July 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
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