Abstract
With recent advances in neonatal intensive care, preterm infants are surviving into
adulthood. Nonetheless, epidemiological data on the health status of these preterm
infants have begun to reveal a worrying theme; prematurity and the supplemental oxygen
therapy these infants receive after birth appear to be risk factors for kidney disease
in adulthood, affecting their quality of life. As the incidence of chronic kidney
disease and the survival time of preterm infants both increase, the management of
the hyperoxia-induced renal disease is becoming increasingly relevant to neonatologists.
The mechanism of this increased risk is currently unknown, but prematurity itself
and hyperoxia exposure after birth may predispose to disease by altering the normal
trajectory of kidney maturation. This article reviews altered renal reactivity due
to hyperoxia, the possible mechanisms of renal injury due to hyperoxia, and the role
of resveratrol in renal injury.
Key Points
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Premature infants commonly receive supplementary oxygen.
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Hyperoxia can cause kidney damage via signal pathways.
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We should reduce the occurrence of late sequelae.
Keywords
resveratrol - hyperoxia - renal injury - CKD
