Enantioselective C–H Functionalization toward Silicon-Stereogenic Silanes

Wei Yuan; Chuan He

doi:10.1055/a-1729-9664

Synthesis, Table of Contents

Synthesis 2022; 54(08): 1939-1950
DOI: 10.1055/a-1729-9664

short review

Enantioselective C–H Functionalization toward Silicon-Stereogenic Silanes

Authors

Wei Yuan
Chuan He ∗

Abstract

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Abstract

In recent years, transition-metal-catalyzed enantioselective C–H bond functionalization has emerged as a powerful and attractive synthetic approach to access silicon-stereogenic centers, which provides impetus for the innovation of chiral organosilicon chemistry. This short review summarizes recent advances in the construction of silicon-stereogenic silanes via transition-metal-catalyzed enantioselective C–H functionalization. We endeavor to highlight the great potential of this methodology and hope that this review will shed light on new perspectives and inspire further research in this emerging area.

1 Introduction

2 Enantioselective C–H Functionalization Induced by Oxidative Addition of an Aryl-OTf Bond

3 Enantioselective C–H Functionalization Induced by Oxidative Addition of a Silacyclobutane

4 Directing-Group-Assisted Enantioselective C–H Functionalization

5 Enantioselective Dehydrogenative C–H/Si–H Coupling

5.1 Enantioselective C(sp²)–H Silylation

5.2 Enantioselective C(sp³)–H Silylation

6 Summary and Outlook

Key words

asymmetric catalysis - enantioselective C–H functionalization - silicon-stereogenic silanes - C–H silylation - organosilicon compounds

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References

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