Abstract
Despite evidence to support the safety and efficacy of COVID-19 vaccination in pregnancy,
and clear recommendations from professional organizations and the Centers for Disease
Control and Prevention (CDC) for pregnant people to get vaccinated, COVID-19 vaccine
hesitancy in pregnancy remains a significant public health problem. The emergence
of the highly transmissible B.1.617.2 (Delta) variant among primarily unvaccinated
people has exposed the cost of vaccine hesitancy. In this commentary, we explore factors
contributing to COVID-19 vaccine hesitancy in pregnancy and potential solutions to
overcome them.
Key Points
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Low COVID-19 vaccination coverage in pregnant people is a major public health problem
in the United States.
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COVID-19 vaccine hesitancy in pregnancy is multifactorial.
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The “4 Cs” framework may be useful in countering COVID-19 vaccine hesitancy.
Keywords
COVID-19 vaccination - vaccine hesitancy - pregnancy - maternal immunization
