Pharmacopsychiatry 2021; 54(05): 240-245
DOI: 10.1055/a-1524-2794
Original Paper

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

Sandeep M. Nayak
1   Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
,
Natalie Gukasyan
1   Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
,
Frederick S. Barrett
1   Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
,
Earth Erowid
2   Erowid Center, Grass Valley, CA, USA
,
Fire Erowid
2   Erowid Center, Grass Valley, CA, USA
,
Roland R. Griffiths
1   Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
3   Department of Neuroscience, Johns Hopkins University School of Medicine, USA
› Institutsangaben
Funding: The Center for Psychedelic and Consciousness Research is funded by philanthropic support from the Steven and Alexandra Cohen Foundation, as well as Tim Ferriss, Matt Mullenweg, Blake Mycoskie, and Craig Nerenberg. NG is also funded by NIDA T32DA07209. The funders had no input on the design, execution, or interpretation of this report.

Abstract

Introduction Psychedelics show promise in treating unipolar depression, though patients with bipolar disorder have been excluded from recent psychedelic trials. There is limited information on the use of classic psychedelics (e. g., LSD or psilocybin) in individuals using mood stabilizers to treat bipolar disorder. This is important to know, as individuals with bipolar depression may attempt to treat themselves with psychedelics while on a mood stabilizer, particularly given enthusiastic media reports of the efficacy of psilocybin for depression.

Methods This study analyzed reports of classic psychedelics administered with mood stabilizers from 3 websites (Erowid.org, Shroomery.org, and Reddit.com).

Results Strikingly, 47% of 62 lithium plus psychedelic reports involved seizures, and an additional 18% resulted in bad trips while none of 34 lamotrigine reports did. Further, 39% of lithium reports involved medical attention. Most of the lamotrigine reports (65%) but few (8%) of the lithium reports were judged to not affect the psychedelic experience.

Discussion Although further research is needed, we provisionally conclude that psychedelic use may pose a significant seizure risk for patients on lithium.

Supplementary Material



Publikationsverlauf

Eingereicht: 28. Februar 2021
Eingereicht: 11. Mai 2021

Angenommen: 25. Mai 2021

Publikationsdatum:
04. August 2021 (online)

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