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Diabetes aktuell 2021; 19(02): 76-80
DOI: 10.1055/a-1452-1412
DOI: 10.1055/a-1452-1412
Schwerpunkt
Autoimmunerkrankung Typ-1-Diabetes
Forschungsansätze und Entwicklung zukünftiger Interventionsstrategien
ZUSAMMENFASSUNG
Die umfassende Erforschung der Immunologie des Typ-1-Diabetes kann entscheidend zu unserem Verständnis der Krankheit beitragen. Hierbei ist insbesondere auch die Identifizierung der zugrundeliegenden Signalwege, die zur fehlerhaften Immuntoleranz sowie der Aktivierung und dem Fortschreiten der Inselautoimmunität beitragen, von entscheidender Bedeutung für die Entwicklung zukünftiger Interventionsstrategien, um die Entstehung von Typ-1-Diabetes zu verlangsamen oder sogar ganz zu verhindern [1]. So bieten kürzlich identifizierte miRNAs, die zur Entstehung von Inselautoimmunität beitragen, einen vielversprechenden Ansatz, um Treg-vermittelte Toleranzdefekte mittels gezielter miRNA-Modulation zu reduzieren.
Publication History
Article published online:
29 April 2021
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Literatur
- 1 Ziegler AG, Bonifacio E. Shortening the paths to type 1 diabetes mellitus prevention. Nat Rev Endocrinol 2021; 17: 73-74 DOI: 10.1038/s41574-020-00450-5.
- 2 Patterson CC, Dahlquist GG, Gyürüs E. et al Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. Lancet 2009; 373: 2027-2033 DOI: 10.1016/S0140-6736(09)60568-7.
- 3 Bonifacio E, Hummel M, Walter M. et al IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes. Diabetes Care 2004; 27: 2695-7000 DOI: 10.2337/diacare.27.11.2695.
- 4 Winkler C, Jolink M, Knopff A. et al Age, HLA, and Sex Define a Marked Risk of Organ-Specific Autoimmunity in First-Degree Relatives of Patients With Type 1 Diabetes. Diabetes Care 2019; 42: 1684-1691 DOI: 10.2337/dc19-0315.
- 5 Hippich M, Beyerlein A, Hagopian WA. et al Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families. Diabetes 2019; 68: 847-857 DOI: 10.2337/db18-0882.
- 6 Ziegler AG, Nepom GT. Prediction and pathogenesis in type 1 diabetes. Immunity 2010; 32: 468-478 DOI: 10.1016/j.immuni.2010.03.018.
- 7 Rodriguez-Calvo T, Richardson SJ, Pugliese A. Pancreas Pathology During the Natural History of Type 1 Diabetes. Curr Diab Rep 2018; 18: 124 DOI: 10.1007/s11892-018-1084-3.
- 8 Steffes MW, Sibley S, Jackson M, Thomas W. Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 2003; 26: 832-836 DOI: 10.2337/diacare.26.3.832.
- 9 Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 04: 330-336 DOI: 10.1038/ni904.
- 10 Serr I, Fürst RW, Ott VB. et al miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity. Proc Natl Acad Sci U S A 2016; 113: E6659-E6668 DOI: 10.1073/pnas.1606646113.
- 11 Serr I, Scherm MG, Zahm AM. et al A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes. Sci Transl Med 2018; 10: eaag1782 DOI: 10.1126/scitranslmed.aag1782.
- 12 Scherm MG, Serr I, Zahm AM. et al miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes. Nat Commun 2019; 10: 5697 DOI: 10.1038/s41467-019-13587-3.
- 13 Ziegler AG, Kick K, Bonifacio E. et al Yield of a Public Health Screening of Children for Islet Autoantibodies in Bavaria, Germany. JAMA 2020; 323: 339-351 DOI: 10.1001/jama.2019.21565.
- 14 Ziegler AG, Rewers M, Simell O. et al Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013; 309: 2473-2479 DOI: 10.1001/jama.2013.6285.
- 15 Serr I, Fürst RW, Achenbach P. et al Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice. Nat Commun 2016; 07: 10991 DOI: 10.1038/ncomms10991.
- 16 Polansky JK, Kretschmer K, Freyer J. et al DNA methylation controls Foxp3 gene expression. Eur J Immunol 2008; 38: 1654-1663 DOI: 10.1002/eji.200838105.
- 17 Scherm MG, Daniel C. miRNA Regulation of T Cells in Islet Autoimmunity and Type 1 Diabetes. Curr Diab Rep 2020; 20: 41 DOI: 10.1007/s11892-020-01325-9.
- 18 Scherm MG, Serr I, Kaestner KH, Daniel C. The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity. Mol Metab 2019; 27 S(Suppl) S122-S128 DOI: 10.1016/j.molmet.2019.06.009.
- 19 Scherm MG, Daniel C. miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes. Front Endocrinol (Lausanne) 2020; 11: 606322 DOI: 10.3389/fendo.2020.606322.