Hamostaseologie 2021; 41(02): 146-153
DOI: 10.1055/a-1401-2706
Review Article

Procoagulant Platelets: Mechanisms of Generation and Action

N.A. Podoplelova
1  Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia
2  National Medical Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
,
D.Y. Nechipurenko
1  Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia
2  National Medical Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
3  Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia
,
A.A. Ignatova
1  Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia
2  National Medical Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
,
A.N. Sveshnikova
1  Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia
2  National Medical Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
3  Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia
,
M.A. Panteleev
1  Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia
2  National Medical Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
3  Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia
› Author Affiliations
Funding The authors were supported by the Russian Science Foundation grant 20-74-00133.

Abstract

During the past decades, it has been increasingly recognized that the major function of accelerating membrane-dependent reactions of blood coagulation is predominantly implemented by a subset of activated platelets. These procoagulant platelets (also called collagen- and thrombin-activated or COAT, coated, necrotic, although there could be subtle differences between these definitions) are uniquely characterized by both procoagulant activity and, at the same time, inactivated integrins and profibrinolytic properties. The mechanisms of their generation both in vitro and in situ have been increasingly becoming clear, suggesting unique and multidirectional roles in hemostasis and thrombosis. In this mini-review, we shall highlight the existing concepts and challenges in this field.



Publication History

Received: 15 December 2020

Accepted: 25 February 2021

Publication Date:
15 April 2021 (online)

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