TY - JOUR AU - Podoplelova, N.A.; Nechipurenko, D.Y.; Ignatova, A.A.; Sveshnikova, A.N.; Panteleev, M.A. TI - Procoagulant Platelets: Mechanisms of Generation and Action SN - 0720-9355 SN - 2567-5761 PY - 2021 JO - Hamostaseologie JF - Hämostaseologie LA - DE VL - 41 IS - 02 SP - 146 EP - 153 DA - 2021/04/15 KW - procoagulant platelets KW - thrombosis KW - hemostasis AB - During the past decades, it has been increasingly recognized that the major function of accelerating membrane-dependent reactions of blood coagulation is predominantly implemented by a subset of activated platelets. These procoagulant platelets (also called collagen- and thrombin-activated or COAT, coated, necrotic, although there could be subtle differences between these definitions) are uniquely characterized by both procoagulant activity and, at the same time, inactivated integrins and profibrinolytic properties. The mechanisms of their generation both in vitro and in situ have been increasingly becoming clear, suggesting unique and multidirectional roles in hemostasis and thrombosis. In this mini-review, we shall highlight the existing concepts and challenges in this field. PB - Georg Thieme Verlag KG DO - 10.1055/a-1401-2706 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1401-2706 ER -