Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study

Hui Shi; Xiao Ni Guan; Dian Ying Liu; Lin Zhu; Zhi Wei Wu; Guo Zhi Luo; Jun Wang; Mei Hong Xiu; Xiang Yang Zhang

doi:10.1055/a-1353-6544

Pharmacopsychiatry, Table of Contents

Pharmacopsychiatry 2021; 54(02): 68-74
DOI: 10.1055/a-1353-6544

Original Paper

Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study

Authors

Hui Shi

¹Department of Clinical Psychology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
Xiao Ni Guan

²Peking University Hui Long Guan Clinical Medical School, Beijing Hui Long Guan Hospital, Beijing, China
Dian Ying Liu

³Department of Psychiatry, The Third People’s Hospital of Ganzhou, Ganzhou, Jiangxi, China
Lin Zhu

³Department of Psychiatry, The Third People’s Hospital of Ganzhou, Ganzhou, Jiangxi, China
Zhi Wei Wu

⁴Department of Psychiatry, Shenzhen Kangning Hospital, Shenzhen, Guangdong, China

⁵Shenzhen Mental Health center. Shenzhen, Guangdong, China
Guo Zhi Luo

⁴Department of Psychiatry, Shenzhen Kangning Hospital, Shenzhen, Guangdong, China

⁵Shenzhen Mental Health center. Shenzhen, Guangdong, China
Jun Wang

²Peking University Hui Long Guan Clinical Medical School, Beijing Hui Long Guan Hospital, Beijing, China
Mei Hong Xiu

²Peking University Hui Long Guan Clinical Medical School, Beijing Hui Long Guan Hospital, Beijing, China
Xiang Yang Zhang

⁶CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China

Abstract

Background Patients with antipsychotic-naïve first-episode (ANFE) schizophrenia (SZ) can help clarify many confounding factors in determining sex differences in antipsychotic drug induced weight gain and its association with symptom improvement.

Methods This 8-week longitudinal trial of ANFE patients with SZ enrolled 526 patients and 313 healthy controls. We evaluated bodyweight and the efficacy of antipsychotics on the Positive and Negative Syndrome Scale (PANSS) at baseline and at the end of week 8.

Results Males and females after treatment showed no sex difference in weight gain, BMI increase, and percentage of weight gain. However, at baseline, male patients had more positive symptoms than female patients, and decreases in positive symptoms, general psychopathology, and total PANSS scores were less in male than female patients. Adjusting for confounding factors using multiple linear regression confirmed that weight gain was significantly associated with these decreases in PANSS symptoms only in men not women.

Conclusions The relationship between weight gain and symptom reduction after 8 weeks of antipsychotic treatment exists only in male patients with ANFE SZ and not in female patients.

Key words

schizophrenia, sex difference, weight gain - therapeutic response - body mass index

Full Text

References

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