Minimal Residual Disease in Neovascular Age-Related Macular Degeneration

Abstract

With the advent of long-acting anti-vascular endothelial growth factor substances, “healing of AMD (age-related macular degeneration)” might be easily assumed due to prolonged treatment intervals. Adoption of the oncological concept of minimal residual disease for quiescent choroidal neovascularization (CNV) lesions might enhance the importance of continued monitoring, and spur research into the core of the disease, i.e., CNV biology.

Zusammenfassung

Mit der Zulassung langwirksamer Anti-VEGF-Substanzen könnte in Zukunft der Eindruck beim Patienten entstehen, eine neovaskuläre altersbedingte Makuladegeneration sei „geheilt“, da lange Intervalle zwischen den einzelnen Behandlungen Realität geworden sind. Die Einführung des onkologischen Konzeptes „Minimal residual Disease“ (MRD) könnte hier die Bedeutung quiescenter, unter Behandlung nicht exsudativer choroidaler Neovaskularisationen wieder mehr in den Fokus rücken, um auf die Wichtigkeit des langfristigen Krankheitsmonitorings hinzuweisen.

Key words

minimal residual disease - complete remission - age-related macular degeneration - AMD - choroidal neovascularization - CNV

Schlüsselwörter

Minimal residual Disease - OCT - altersbedingte Makuladegeneration (Age-related macular Degeneration) - OCT

Publication History

Received: 04 November 2020

Accepted: 27 November 2020

Article published online:
14 April 2021

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