Klin Monbl Augenheilkd 2022; 239(02): 185-190
DOI: 10.1055/a-1327-3156
Experimentelle Studie

The Effectiveness of Corneal Epithelial Debridement Performed with an Alcohol-Impregnated Sponge

Die Wirksamkeit einer mit einem alkoholgetränkten Schwamm durchgeführten Hornhautepithelwundausschneidung
Deniz Altinbay
Niv Eye Center, Adana, Turkey
,
Ibrahim Taskin
Niv Eye Center, Adana, Turkey
› Institutsangaben

Abstract

Objective To evaluate the clinical outcomes of patients who underwent corneal surgery with debridement of epithelium by localised application of an alcohol-impregnated sponge instead of the usual alcohol reservoir method.

Design This study retrospectively included 52 eyes of 27 patients who underwent LASEK (laser-assisted subepithelial keratectomy) and CXL (cross-linking) surgery after application of this alcohol-assisted debridement method between January 2019 and April 2019.

Participants Twenty-four patients who underwent LASEK and three patients who underwent CXL surgery were included in this study, which comprised a total of 52 eye operations.

Methods Epithelial debridement was performed after placing a 20% ethanol-impregnated sponge on the cornea for 20 seconds.

Results The mean pachymetry value was 509.40 ± 30.37 µm, the mean preoperative spherical equivalent was − 2.14 ± 1.02 dioptres, and the highest myopia and astigmatism values were − 4.25 dioptres and − 2.75 dioptres, respectively. It was seen that the corneal epithelium was completely and easily debrided in a size identical to that of the applied sponge.

Conclusions Complete debridement of the corneal epithelium can be performed quickly, safely, and easily with this specially prepared sponge.

Zusammenfassung

Ziel Bewertung der klinischen Ergebnisse von Patienten, bei denen Hornhautoperationen mit Wundausschneidung des Epithels durch lokalisierte Anwendung eines alkoholimprägnierten Schwamms anstelle der üblichen Methode des Alkoholreservoirs durchgeführt wurden.

Design Diese Studie umfasste retrospektiv 52 Augen von 27 Patienten, die sich nach Anwendung dieser alkoholunterstützten Wundausschneidungsmethode zwischen Januar 2019 und April 2019 einer LASEK- und CXL-Operation unterzogen hatten.

Teilnehmer 24 Patienten, bei denen eine LASEK (laserunterstützte subepitheliale Keratektomie) durchgeführt wurde, und 3 Patienten, bei denen eine CXL-Operation (Vernetzung) durchgeführt wurde, wurden in diese Studie, die insgesamt 52 Augenoperationen umfasste, eingeschlossen.

Methodik Die Wundausschneidung wurde durchgeführt, indem dieses Material nach Imprägnierung mit 20% Ethanol auf die Hornhaut gelegt wurde.

Ergebnisse Der mittlere Pachymetriewert betrug 509,40 ± 30,37 µm, das mittlere präoperative sphärische Äquivalent betrug − 2,14 ± 1,02 Dioptrien und die höchsten Myopie- und Astigmatismuswerte betrugen jeweils − 4,25 und − 2,75 Dioptrien. Es wurde beobachtet, dass das Hornhautepithel in einer Größe, die mit der des aufgebrachten Schwamms identisch war, vollständig und leicht gereinigt wurde.

Schlussfolgerungen Mit diesem speziell vorbereiteten Schwamm kann das Hornhautepithel schnell, sicher, vollständig und einfach gereinigt werden.

Highlights
  • Many surgeons perform alcohol-assisted debridement with reservoir cones containing 20% ethanol dilutions, which can spill out.

  • Using an alcohol-impregnated sponge instead of alcohol cone does not require manual pressure over the ocular globe.

  • It has been observed that the corneal epithelium can be debrided in a circular, complete, fast and easy manner with specially prepared circular material.

  • The histological changes in the limbus and conjunctiva should be examined to prove that alcohol is in contact less and the toxic effects of alcohol can be reduced with this method.



Publikationsverlauf

Eingereicht: 27. Juli 2020

Angenommen: 29. Oktober 2020

Artikel online veröffentlicht:
17. März 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Alio JL, Ismael MM, Artola A. Laser epithelium removal before photorefractive keratectomy. J Refract Surg 1993; 9: 395
  • 2 Pallikaris IG, Karoutis AD, Lydataki SE. et al. Rotating brush for fast removal of corneal epithelium. J Refract Surg 1994; 10: 439-442
  • 3 Johnson DG, Kezirian GM, George SP. et al. Removal of corneal epithelium with phototherapeutic technique during multizone, multipass photorefractive keratectomy. J Refract Surg 1998; 14: 38-48
  • 4 Kapadia MS, Meisler DM, Wilson SE. Epithelial removal with the excimer laser (laser-scrape) in photorefractive keratectomy retreatment. Ophthalmology 1999; 106: 29-34
  • 5 Carones F, Fiore T, Brancato R. Mechanical vs. alcohol epithelial removal during photorefractive keratectomy. J Refract Surg 1999; 15: 556-562
  • 6 Litwak S, Zadok D, Garcia-De Quevedo V. et al. Laser-assisted subepithelial keratectomy versus photorefractive keratectomy for the correction of myopia: a prospective comparative study. J Cataract Refract Surg 2002; 28: 1330-1333
  • 7 Shah S, Doyle S, Chatterjee A. et al. Comparison of 18 % ethanol and mechanical debridement for epithelial removal before photorefractive keratectomy. J Refract Surg 1998; 14: S212-S214
  • 8 Kanitkar KD, Camp J, Humble H. et al. Pain after epithelial removal by ethanol-assisted mechanical versus transepithelial excimer laser debridement. J Refract Surg 2000; 16: 519-522
  • 9 Gimbel HV, Debroff BM, Beldavs RA. et al. Comparison of laser and manual removal of corneal epithelium for photorefractive keratectomy. J Refract Surg 1995; 11: 36-67
  • 10 Campos M, Hertzog L, Wang XW. et al. Corneal surface after deepithelialization using a sharp and a dull instrument. Ophthalmic Surg 1992; 23: 618-621
  • 11 Calabuig RB, Lopez FG, Casaponsa JRV. Combined ethanol-assisted and blunt mechanical corneal epithelial peeling technique. J Emmetropia 2014; 5: 145-149
  • 12 Ghoreishi M, Attarzadeh H, Tavakoli M. et al. Alcohol-assisted versus mechanical epithelium removal in photorefractive keratectomy. J Ophthalmic Vis Res 2010; 5: 223
  • 13 Abad JC, Talamo JH, Vidaurri-Leal J. et al. Dilute ethanol versus mechanical debridement before photorefractive keratectomy. J Cataract Refract Surg 1996; 22: 1427-1433
  • 14 Abad JC, An B, Power WJ. et al. A prospective evaluation of alcohol-assisted versus mechanical epithelial removal before photorefractive keratectomy. Ophthalmology 1997; 104: 1566-1575
  • 15 Einollahi B, Baradaran-Rafii A, Rezaei-Kanavi M. et al. Mechanical versus alcohol-assisted epithelial debridement during photorefractive keratectomy: a confocal microscopic clinical trial. J Refract Surg 2011; 27: 887-893
  • 16 Bilbao-Calabuig R, Gonzalez-Lopez F, Calvo Arrabal M. et al. Safety and efficacy of Photorefractive Keratectomy (PRK) for myopia using a new corneal epithelium debridement technique. J Emmetropia 2015; 6: 133-137
  • 17 Campos M, Raman S, Lee M. et al. Keratocyte loss after different methods of de-epithelialization. Ophthalmology 1994; 101: 890-894
  • 18 Campos M, Szerenyi K, Lee M. et al. Keratocyte loss after corneal deepithelialization in primates and rabbits. Arch Ophthalmol 1994; 112: 254-260
  • 19 Oh JY, Yu JM, Ko JH. Analysis of ethanol effects on corneal epithelium. Invest Ophthalmol Vis Sci 2013; 54: 3852-3856
  • 20 Zhang P, Liu M, Liao R. Toxic effect of using twenty percent alcohol on corneal epithelial tight junctions during LASEK. Mol Med Rep 2012; 6: 33-38
  • 21 Stein HA, Stein RM, Price C. et al. Alcohol removal of the epithelium for excimer laser ablation: outcomes analysis. J Cataract Refract Surg 1997; 23: 1160-1163
  • 22 OʼDoherty M, Kirwan C, OʼKeeffe M. et al. Postoperative pain following epi-LASIK, LASEK, and PRK for myopia. J Refract Surg 2007; 23: 133-138
  • 23 Ghanem VC, Souza GC, Souza DC. et al. PRK and butterfly LASEK: prospective, randomized, contralateral eye comparison of epithelial healing and ocular discomfort. J Refract Surg 2008; 24: 591-599
  • 24 OʼBrart DP. Excimer laser surface ablation: a review of recent literature. Clin Exp Optom 2014; 97: 12-17
  • 25 Subasinghe SK, Ogbuehi KC, Dias GJ. Current perspectives on corneal collagen crosslinking (CXL). Graefes Arch Clin Exp Ophthalmol 2018; 256: 1363-1384