Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

Abstract

Three new depsidones, parmosidones F – G (1 – 2), and 8′-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A – C (4 – 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive spectroscopic analyses and comparison with literature data. The isolated polyphenolics were assayed for their α-glucosidase inhibitory activities. Newly reported benzylated depsidones 1 and 2 in particular inhibited α-glucosidase with IC₅₀ values of 2.2 and 4.3 µM, respectively, and are thus more potent than the positive control, acarbose.

Key words

depsidones - Diphenylethers - α-glucosidase - Lichens - Polyphenolics - Parmotrema dilatatum

^* These authors contributed equally to this work (co-first authors).

^** These authors contributed equally to this work (co-last authors).

Publication History

Received: 24 February 2020

Accepted after revision: 12 June 2020

Article published online:
20 August 2020

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