Klin Monbl Augenheilkd
DOI: 10.1055/a-1179-0131
Klinische Studie

The Impact of Artificial Tear Viscosity on the Results of Optical Coherence Tomography

Article in several languages: English | deutsch
Elisa Hannemann
1  Optometrie, Fachbereich VII, Beuth Hochschule für Technik, Berlin
,
Carl Erb
2  Augenklinik am Wittenbergplatz, Berlin
› Author Affiliations

Abstract

Background In earlier studies, an irregular tear film could be responsible for artifacts in imaging procedures in ophthalmology. As a result, this study will investigate the influence of hyaluronic acid-containing tear substitutes of different viscosities on the measurement results of optical coherence tomography and on the non-invasive tear film break-up time.

Methods The study included three sessions in which three hyaluronic acid tear substitutes of different viscosities (Hylo-Vision 0.1%, 0.2%, 0.3%, OmniVision GmbH, Puchheim, Germany) were applied to each subject. In 20 healthy volunteers, the non-invasive tear film break-up time was measured before and after the application of the tear substitutes using Keratograph 5M (Oculus GmbH, Wetzlar, Germany) and optical coherence tomography using 3D OCT-2000 (Topcon, Hamburg, Germany).

Results The median age of the volunteers was 28.5 years. 11 women (55%) and 9 men (45%) were examined. The non-invasive tear film break-up time improved significantly (p = 0.027) after the application of 0.3% hyaluronic acid. In the study, no significant difference was found in all OCT parameters used before and after application of the different viscous hyaluronic acid-containing tear substitutes.

Conclusion In this study, no influence of tear substitutes containing different viscosities of hyaluronic acid on the measurement results of optical coherence tomography could be determined. Therefore, 0.1%, 0.2% and 0.3% hyaluronic acid can be applied to the patient to improve the corneal surface before the examination with optical coherence tomography, without influencing the measurement results of optical coherence tomography.



Publication History

Received: 24 September 2019

Accepted: 16 April 2020

Publication Date:
09 October 2020 (online)

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