Pharmacopsychiatry
DOI: 10.1055/a-1151-4947
Review
© Georg Thieme Verlag KG Stuttgart · New York

Synchronization of Fibroblasts Ex Vivo in Psychopharmacology

Frank Faltraco
1  Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany
,
Adriana Uzoni
1  Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany
,
Liliia Shevchuk
1  Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany
,
Johannes Thome
1  Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany
,
Denise Palm
1  Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany
› Author Affiliations
Further Information

Publication History

received 28 December 2018
revised 05 March 2020

accepted 01 April 2020

Publication Date:
27 April 2020 (online)

Abstract

The central oscillator for the inner clock is the suprachiasmatic nuclei of the hypothalamus. Furthermore, many peripheral oscillators are present in tissues such as skin. Human derived fibroblasts provide an advantageous model to study circadian rhythmicity as well as the influence of pharmacological drugs on circadian gene expression. Importantly, the synchronization of the circadian system of fibroblasts can be done by different methods. The review presents an overview of the current knowledge of different synchronization methods mostly used in mice or rat fibroblasts. Furthermore, the review sums up and discusses the role of norepinephrine as a possible synchronizer agent.