Planta Med 2020; 86(04): 224-238
DOI: 10.1055/a-1087-8276
Biological and Pharmacological Activity
Georg Thieme Verlag KG Stuttgart · New York

Current State of the Art on the Antioxidant Activity of Sage (Salvia spp.) and Its Bioactive Components

Efthymios Poulios
Department of Food Science and Nutrition, School of the Environment, University of the Aegean, Lemnos, Greece
Constantinos Giaginis
Department of Food Science and Nutrition, School of the Environment, University of the Aegean, Lemnos, Greece
Georgios K. Vasios
Department of Food Science and Nutrition, School of the Environment, University of the Aegean, Lemnos, Greece
› Author Affiliations
Further Information

Publication History

received 11 September 2019
revised 19 December 2019

accepted 25 December 2019

Publication Date:
23 January 2020 (online)


Common sage (Salvia spp., with the most common species Salvia officinalis) is an important medicinal and aromatic plant due to its bioactive components, secondary products of its metabolism. These components are mainly phenolics, terpenoids, polyphenols, and flavonoids. Many studies have identified their important role in fighting oxidative stress in cells and organisms, together with their anticancer, antimicrobial, and anti-inflammatory role. There are many methods measuring the antioxidant activity of sage phenolic components, usually based on radical scavenging of free radical species, such as 2,2-diphenyl-1-picrylydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and determining the absorbance of the reduced product by a photometric assay. In addition, there are several in vitro and in vivo studies determining the protection of sage extracts in cells in culture or animals, respectively, after induction of oxidative stress. In this review, results from the currently available studies that unravel the significant role of sage bioactive compounds, as antioxidant compounds, and the variety of methods used have been critically analyzed and discussed.

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