Klin Monbl Augenheilkd 2020; 237(04): 519-520
DOI: 10.1055/a-1068-9073
Der interessante Fall
Georg Thieme Verlag KG Stuttgart · New York

The Slowly Progressive, Bilaterally Simultaneous Variety of Leber Hereditary Optic Neuropathy

Die langsam fortschreitende, beidseitig gleichzeitige Art der Leberʼschen hereditären Optikusneuropathie
Armin Handzic
Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland
,
Misha L. Pless
Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland
› Author Affiliations
Further Information

Publication History

received 25 September 2019

accepted 18 November 2019

Publication Date:
27 March 2020 (online)

Background

Leber hereditary optic neuropathy (LHON) is one of the most common inherited optic neuropathies causing bilateral central vision loss. The disorder results from point mutations in mitochondrial DNA (mtDNA). The primary cell type that is lost is the retinal ganglion cell. The clinical phenotype is highly variable.