Pharmacopsychiatry
DOI: 10.1055/a-1027-7055
Review
© Georg Thieme Verlag KG Stuttgart · New York

Circadian Clocks in the Regulation of Neurotransmitter Systems

Jana-Thabea Kiehn
1  Institute of Neurobiology, University of Lübeck, Lübeck, Germany
,
Frank Faltraco
2  Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
,
Denise Palm
2  Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
,
Johannes Thome
2  Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
,
Henrik Oster
1  Institute of Neurobiology, University of Lübeck, Lübeck, Germany
› Author Affiliations
Further Information

Publication History

received 21 December 2018
revised 28 August 2019

accepted 08 October 2019

Publication Date:
30 October 2019 (online)

Abstract

To anticipate and adapt to daily recurring events defined by the earth’s rotation such as light-dark and temperature cycles, most species have developed internal, so-called circadian clocks. These clocks are involved in the regulation of behaviors such as the sleep-wake cycle and the secretion of hormones and neurotransmitters. Disruptions of the circadian system affect cognitive functions and are associated with various diseases that are characterized by altered neurotransmitter signaling. In this review, we summarize the current knowledge about the interplay of the circadian clock and the regulation of psychiatric health and disease.