Endoscopy 2020; 52(01): 68-72
DOI: 10.1055/a-1008-9077
Innovations and brief communications
© Georg Thieme Verlag KG Stuttgart · New York

Full-thickness resection of neuroendocrine tumors in the rectum

Benjamin Meier
1  Department of Gastroenterology, Klinikum Ludwigsburg, Ludwigsburg, Germany
Heinz Albrecht
2  Department of Gastroenterology, Klinikum Neumarkt, Neumarkt in der Oberpfalz, Germany
Thomas Wiedbrauck
3  Department of Gastroenterology, Malteser Krankenhaus St. Anna, Duisburg, Germany
Arthur Schmidt
4  Department of Medicine II, Medical Center, University of Freiburg, Faculty of Medicine, Freiburg, Germany
Karel Caca
1  Department of Gastroenterology, Klinikum Ludwigsburg, Ludwigsburg, Germany
› Author Affiliations
Further Information

Publication History

submitted: 10 December 2018

accepted after revision: 09 August 2019

Publication Date:
15 October 2019 (online)


Background Rectal neuroendocrine tumors (NETs) are subepithelial tumors with potential for malignancy. Depending on tumor characteristics, endoscopic or surgical resection is recommended. However, the optimal endoscopic approach is not defined. This is the first larger study evaluating endoscopic full-thickness resection (EFTR) of rectal NETs.

Methods For resection, the full-thickness resection device (FTRD) was used. A registry was created as part of post-market clinical follow-up. All cases of rectal NETs in the registry were analyzed retrospectively.

Results 31 German centers entered data of 501 FTRD procedures and 40 cases of rectal NETs were identified. The median lesion size was 8 mm. All lesions could be resected using FTRD. The median procedure time was 18.5 minutes. Resection was macroscopically and histologically complete in all cases. Full-thickness resection was achieved in 95 %. No major adverse events occurred. Endoscopic follow-up showed no evidence of residual or recurrent tumor.

Conclusion EFTR is safe and effective for resection of smaller rectal NETs. Prospective comparative trials are needed to define the role of EFTR of rectal NETs.