Pharmacopsychiatry, Table of Contents Pharmacopsychiatry 2019; 52(06): 280-281DOI: 10.1055/a-0902-5145 Commentary © Georg Thieme Verlag KG Stuttgart · New YorkCan Kampo and Dietary Supplement Address Unmet Need? – A Commentary on Tatsumi et al. and Hoffmann et al. Authors Author Affiliations Takashi Tsuboi 1 Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan Recommend Article Abstract Buy Article(opens in new window) Full Text References References 1 Tatsumi L, Suzuki T, Yamada K. et al. Kampo, A Japanese traditional medicinal system for psychiatric conditions: A narrative review. Pharmacopsychiatry 2019; 52: 251-260 2 Hoffmann K, Emons B, Brunnhuber S. et al. Dietary supplements in psychiatric treatment – A narrative review.. Pharmacopsychiatry 2019; 52: 261-279 3 Suehs B, Argo TR, Bendele SD. et al. The Texas Medication Algorithm Project (TMAP) major depressive disorder algorithms. Texas Department of State Health Services 2008; 1-71 4 Lin PY, Mischoulon D, Freeman MP. et al. Are omega-3 fatty acids antidepressants or just mood-improving agents? The effect depends upon diagnosis, supplement preparation, and severity of depression. Mol Psychiatry 2012; 17: 1161-1163 5 Martins JG, Bentsen H, Puri BK. Eicosapentaenoic acid appears to be the key omega-3 fatty acid component associated with efficacy in major depressive disorder: a critique of Bloch and Hannestad and updated meta-analysis. Mol Psychiatry 2012; 17: 1144-1149 6 Grosso G, Pajak A, Marventanoet S. et al. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One 2014; 9: e96905 7 Amminger GP, Schäfer MR, Papageorgiou K. et al. Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 2010; 67: 146-154 8 Amminger GP, Schäfer MR, Schlögelhofer M. et al. Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study. Nat Commun 2015; 6: 7934 9 Yasuno F, Tanimukai S, Sasaki M. et al. Combination of antioxidant supplements improved cognitive function in the elderly. J Alzheimers Dis 2012; 32: 895-903 10 Fried LP, Tangen CM, Walston J. et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: 146-156 11 Soysal P, Veronese N, Thompson T. et al. Relationship between depression and frailty in older adults: A systematic review and meta-analysis. Ageing Res Rev 2017; 36: 78-87 12 Uto NS, Amitani H, Atobe Y. et al. Herbal medicine Ninjin’yoeito in the treatment of Sarcopenia and Frailty. Front Nutr 2018; 5: 126 13 Sakisaka N, Mitani K, Sempuku S. et al. A clinical study of Ninjin’yoeito with regard to Frailty. Front Nutr 2018; 5: 73