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Klin Monbl Augenheilkd 2018; 235(06): 689-696
DOI: 10.1055/a-0592-7925
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Recurrent Corneal Erosions in Corneal Dystrophies: a Review of the Pathogenesis, Differential Diagnosis, and Therapy

Wiederkehrende Hornhauterosionen bei Hornhautdystrophie: eine Übersicht der Pathogenese, Differenzialdiagnose und Therapie
Amro A. Omari
Department of Ophthalmology and Visual Sciences, W. K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States
,
Shahzad I. Mian
Department of Ophthalmology and Visual Sciences, W. K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States
› Author Affiliations
Further Information

Publication History

received 06 December 2017

accepted 23 February 2018

Publication Date:
12 June 2018 (online)

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Abstract

Introduction Recurrent corneal erosions in corneal dystrophies are visually significant and bothersome to patients. The goal of this article is to review the pathogenesis, differential diagnosis, and management of recurrent corneal erosions in corneal dystrophies.

Patients and Methods Forty-eight articles and 1 textbook recently published on corneal erosions in corneal dystrophies were reviewed. The findings on the pathogenesis and clinical characteristics of erosions in each dystrophy were summarized. Any contradicting opinions for which the literature was unclear were either omitted or recorded as lacking strong evidence.

Results and Conclusions The epithelial-stromal complex plays an important role in the pathogenesis of erosions in corneal dystrophies. The clinical features of each corneal dystrophy guide their diagnosis and management. A better understanding of the pathogenesis and clinical features of erosions in corneal dystrophies can lead to better clinical outcomes.

Zusammenfassung

Einleitung Wiederkehrende Hornhauterosionen bei Hornhautdystrophien haben visuelle Auswirkungen, die für den Patienten sehr lästig sind. Ziel dieses Artikels ist es, einen Überblick über die Pathogenese, Differenzialdiagnose und das Management von wiederkehrenden Hornhauterosionen bei Hornhautdystrophie zu geben.

Patienten und Methoden Diese Überblicksdarstellung beruht auf der Durchsicht von 48 Artikeln sowie einem vor Kurzem publizierten Lehrbuch über Hornhauterosionen bei Hornhautdystrophien. Die Erkenntnisse über Pathogenese und klinische Merkmale von Erosionen bei allen Dystrophien wurden zusammengefasst. Widersprüchliche Meinungen, für die es in der Literatur keine klaren Aussagen gab, wurden entweder weggelassen oder mit dem Vermerk versehen, dass es hierfür keine überzeugenden Beweise gibt.

Ergebnisse und Schlussfolgerungen Wechselwirkungen zwischen Epithel und Stroma spielen bei der Pathogenese von Erosionen in der Hornhautdystrophie eine wichtige Rolle. Bei jeder Hornhautdystrophie bestimmen die klinischen Merkmale die Diagnose und das Management. Ein besseres Verständnis von der Pathogenese und den klinischen Merkmalen von Erosionen bei Hornhautdystrophien kann zu besseren klinischen Ergebnissen führen.

Key words

recurrent corneal erosions - corneal dystrophy

Schlüsselwörter

Hornhauterosion - Hornhautdystrophie
 

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