Early Second-Trimester Spontaneous Miscarriage Due to Fourth Ventricle Choroid Plexus Papilloma

George S. Stoyanov; Ina Kobakova; Dimo Stoyanov; Marin Zhelezov; Meglena Angelova; Deyan Dzhenkov; Reneta Georgieva; Lora Ayetola; Emil Kovachev; Peter Ghenev; Anton B. Tonchev

doi:10.1007/s40556-018-0175-1

Journal of Fetal Medicine, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Journal of Fetal Medicine 2018; 05(03): 163-165
DOI: 10.1007/s40556-018-0175-1

Original Article

Early Second-Trimester Spontaneous Miscarriage Due to Fourth Ventricle Choroid Plexus Papilloma

George S. Stoyanov

¹Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Hristo Smirnenski 1 Blvd., 9002, Varna, Bulgaria

²Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria

³Department of Physiology and Pathophysiology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria

,

Ina Kobakova

¹Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Hristo Smirnenski 1 Blvd., 9002, Varna, Bulgaria

,

Dimo Stoyanov

²Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria

,

Marin Zhelezov

²Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria

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Meglena Angelova

²Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria

,

Deyan Dzhenkov

¹Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Hristo Smirnenski 1 Blvd., 9002, Varna, Bulgaria

,

Reneta Georgieva

⁴Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria

,

Lora Ayetola

⁴Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria

,

Emil Kovachev

⁵Department of Obstetrics and Gynecology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria

,

Peter Ghenev

¹Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Hristo Smirnenski 1 Blvd., 9002, Varna, Bulgaria

,

Anton B. Tonchev

²Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria

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Abstract

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Abstract

Miscarriage due to fetal tumors is an extremely rare finding, with a varying incidence from 1.7 to 13.5 per 100,000 live births, with central nervous system tumors occupying a minority of these cases. Herein, we report the gross morphological and histological findings of a 17-gestational week spontaneous miscarriage in a 27 year old multi-gravida due to a fourth ventricle choroid plexus papilloma (CPP). The CPP was composed of a pronoun fibro-vascular stroma covered with a dense lining of tall cuboid sparsely ciliated single cell layer with rich in chromatin nuclei. The cytoplasm of the CPP covering cells was intensely colored when compared to the pale cytoplasm of the covering cells of the choroid plexus collected from the lateral ventricle, which also lacked in such pronoun fibrovascular stroma. The fourth ventricle was significantly dilated with parenchymal compression of nervous tissue towards the chondral fetal cranium.

Keywords

Spontaneous miscarriage - Fetal tumor - Choroid plexus papilloma - Turner syndrome

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