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CC BY-NC-ND 4.0 · Journal of Fetal Medicine 2016; 03(02): 55-61
DOI: 10.1007/s40556-016-0087-x
Review Article

Prediction of Pre-eclampsia

Kanwal Gujral
1   Institute of Obstetrics and Gynaecology, Sir Ganga Ram Hospital, Rajinder Nagar, 110060, New Delhi, India
,
Sakshi Nayar
2   Department of Obstetrics and Gynaecology, Lady Hardinge Medical College & Smt. S. K. Hospital, New Delhi, India
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Abstract

Pre-eclampsia (PE) is a disease of high maternal, fetal, and neonatal mortality and morbidity. Early recognition, ideally in the first trimester of women at risk for PE will enable prophylaxis and help reduce associated adverse outcomes. No single test is supported by robust evidence to predict PE and no single test has emerged as a front runner. Screening based on risk factors has low sensitivity. Uterine artery Doppler is the primary screening modality for prediction of PE. Individually, no biomarker has shown to have sufficient clinical value in prediction of PE. However, sFlt-1/PlGF ratio performs better than others. A combination of uterine artery Doppler, maternal serum biomarkers, and maternal characteristics offers best predictive power at the moment.

Keywords

Pre-eclampsia - Prediction of pre-eclampsia - Screening of pre-eclampsia


Publication History

Received: 28 December 2015

Accepted: 13 April 2016

Article published online:
08 May 2023

© 2016. Society of Fetal Medicine. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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