Zusammenfassung
Im Jahr 2005 veröffentlichten die Deutsche Gesellschaft für Neurologie und die Deutsche
Schlaganfallgesellschaft Leitlinien zur Primär- und Sekundärprävention des Schlaganfalls.
In der Zwischenzeit hat sich aber durch eine Vielzahl neuer Studien die Notwendigkeit
ergeben die Leitlinien zu aktualisieren.
Abstract
In 2005 the German Neurological Society and the German Stroke Society published recommendations
for the primary and secondary prevention of stroke. In the meantime the results from
many randomised trials became available. This leads to the necessity to update the
recommendations.
Literatur
1 Diener H, Allenberg J-R, Bode C. et al .
Primär- und Sekundärprävention der zerebralen Ischämie. In: Diener H, Putzki N, Berlit P et al. (Hrsg) Leitlinien für Diagnostik und Therapie
in der Neurologie. 3. aktualisierte und erweiterte Auflage. Stuttgart; Thieme 2005:
192-214
2
Pi-Sunyer F X, Aronne L J, Heshmati H M. et al .
Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic
risk factors in overweight or obese patients: RIO-North America: a randomized controlled
trial.
JAMA.
2006;
295
761-775
3
Despres J P, Golay A, Sjostrom L.
Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia.
N Engl J Med.
2005;
353
2121-2134
4
Connolly S, Pogue J, Hart R. et al. (ACTIVE Writing Group on behalf of the ACTIVE
Investigators) .
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the
Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events
(ACTIVE W): a randomised controlled trial.
Lancet.
2006;
367
1903-1912
5
The ESPRIT Study Group .
Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial
origin (ESPRIT): randomised controlled trial.
Lancet.
2006;
367
1665-1673
6
Diener H C, Cuhna L, Forbes C. et al (European Stroke Prevention Study 2.) .
Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke.
J Neurol Sci.
1996;
143
1-13
7
Bhatt D L, Topol E J.
Clopidogrel added to aspirin versus aspirin alone in secondary prevention and high-risk
primary prevention: rationale and design of the Clopidogrel for High Atherothrombotic
Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial.
Am Heart J.
2004;
148
263-268
8
Diener H C, Bogousslavsky J, Brass L M. et al .
Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke
or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind,
placebo-controlled trial.
Lancet.
2004;
364
331-337
9
Mas J L. et al., for the EVA-3S Investigators .
Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis.
N Engl J Med.
2006;
355
1660-1671
10
The Space Collaborative Group .
30 day results from the SPACE trial of stent-protected angioplasty versus carotid
endarterectomy in symptomatic patients: a randomised non-inferiority trial.
Lancet.
2006;
368
1239-1247
11
Amarenco P, Labreuche J, Lavallee P, Touboul P.
Statins in Stroke Prevention and Carotid Atherosclerosis: Systematic Review and Up-to-Date
Meta-Analysis.
Stroke.
2004;
35
2902-2909
12
The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators
.
High-dose atorvastatin after stroke or transient ischemic attack.
N Engl J Med.
2006;
355
549-559
13
Collins R, Armitage J, Parish S. et al., Heart Protection Study Collaborative Group
.
Effects of cholesterol-lowering with simvastatin on stroke and other major vascular
events in 20 536 people with cerebrovascular disease or other high-risk conditions.
Lancet.
2004;
363
757-767
14
Bonaa K H, Njolstad I, Ueland P M. et al .
Homocysteine lowering and cardiovascular events after acute myocardial infarction.
N Engl J Med.
2006;
354
1578-1588
15
The Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators .
Homocysteine lowering with folic acid and B vitamins in vascular disease.
N Engl J Med.
2006;
354
1567-1577
16
Toole J F, Malinow M R, Chambless L E. et al .
Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke,
myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP)
randomized controlled trial.
JAMA.
2004;
291
565-575
Prof. Dr. Hans-Christoph Diener
Universitätsklinik für Neurologie, Universitätsklinikum Essen
Hufelandstr. 55
45147 Essen
Email: hans.diener@uni-duisburg-essen.de