Sulpiride (SULP), a substituted benzamide with high selectivity for D2-like dopamine receptors, has a chiral structure and is used in most countries as
the racemate. In an open pilot study, we investigated 26 inpatients (13 female, 13
male) with schizophrenic or depressive disorder treated with SULP (mean daily dosage
64 - 1062 mg) administered orally, either as a monotherapy or as an add-on treatment
to a stable and unchanged medication for 3 - 60 days. Serum levels of total SULP and
of its enantiomers were measured by high-performance liquid chromatography (HPLC)
procedures. Clinically relevant indicators of hepatic and renal function as well as
retrospectively assessed clinical outcome parameters were correlated with serum levels
of racemic SULP, L-SULP, D-SULP, and the L : D-SULP ratio. A significant correlation
between mean daily dosage and serum levels of SULP, L-SULP, and D-SULP emerged (p < 0.05) which was not influenced by age, gender, diagnosis, hepatic, or renal function.
The ratio of L : D-SULP serum levels was < 1 (range 0.66 - 0.97) in all patients.
A slight negative correlation between CGI improvement and the ratio of L : D-SULP
(p < 0.10) and a positive correlation between racemic SULP concentrations and side-effects
at endpoint was found (p < 0.05).
References
- 1
Benkert O, Holsboer F.
Effect of sulpiride in endogenous depression.
Acta Psychiatr Scand.
1984;
311
43-48
- 2
Bressolle F, Faure-Jeantis A.
Absolute bioavailability, rate of absorption, and dose proportionality of sulpiride
in humans.
J Pharm Sci.
1992;
81
26-32
- 3 Collegium Internationale Psychiatriae Scalarum (CIPS). Weinheim; Beltz 1988
- 4
Crescimanno G, Sorbera F, Emmi A, Amato G.
Inhibitory effect of A10 dopaminergic neurons of the ventral tegmental area on the
orienting response evoked by acoustic stimulation in the cat.
Brain Res Bull.
1998;
45
61-65
- 5
Dahl S G.
Pharmacokinetics of neuroleptic drugs and the utility of plasma level monitoring.
Psychopharmacol Ser.
1988;
5
34-46
- 6
Dahl S G.
Plasma level monitoring of antipsychotic drugs. Clinical utility.
Clin Pharmacokinet.
1986;
11
36-61
- 7
Edwards J G, Alexander J R, Alexander M S, Gordon A, Zutchi T.
Controlled trial of sulpiride in chronic schizophrenia.
Br J Psychiatry.
1980;
137
522-529
- 8
Gerlach J, Behnke K, Heltberg J, Munk-Anderson E, Nielsen H.
Sulpiride and haloperidol in schizophrenia: a double-blind cross-over study of therapeutic
effect, side effects and serum concentrations.
Br J Psychiatry.
1983;
147
283-288
- 9
Lane R M, Baker G B.
Chirality and drugs used in psychiatry: nice to know or need to know?.
Cell Mol Neurobiol.
1999;
19
355-372
- 10
Maier W, Benkert O.
Treatment of chronic depression with sulpiride: evidence of efficacy in placebo-controlled
single case studies.
Psychopharmacology.
1994;
115
495-501
- 11
Mauri M C, Bitetto A, Fabiano L, Laini V, Steinhilber C, Fornier M, Rafique F.
Depressive symptoms and schizophrenic relapses: the effect of four neuroleptic drugs.
Prog Neuropsychopharmacol Biol Psychiatry.
1999;
23
43-54
- 12
Mucci A, Nolfe G, Maj M.
Levosulpiride: a review of its clinical use in psychiatry.
Pharmacol Res.
1995;
31
95-101
- 13
Polatti F.
Sulpiride isomers and milk secretion in puerperium.
Clin Exp Obstet Gynecol.
1982;
9
144-147
- 14
Rao V A, Bailey J, Bishop M, Coppen A.
A clinical and pharmacodynamic evaluation of sulpiride.
Psychopharmacology.
1981;
73
77-80
- 15
Rietbrock S, Merz P G, Fuhr U, Harder S, Marschner J P, Loew D, Biehl J.
Absorption behavior of sulpiride described using Weibull functions.
Int J Clin Pharmacol Ther.
1995;
33
299-303
- 16
Russell V, de Villiers A, Sagvolden T, Lamm M, Taljaard J.
Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate-putamen
of an animal model of attention-deficit hyperactivity disorder - the spontaneously
hypertensive rat.
Brain Res.
1995;
676
343-351
- 17
Rüther E, Degner D, Munzel U, Brunner E, Lenhard G, Biehl J, Vogtle-Junkert U.
Antidepressant action of sulpiride. Results of a placebo-controlled double-blind trial.
Pharmacopsychiat.
1999;
32
127-135
- 18 Seeman P.
Dopamine receptors: Clinical correlates. In: Bloom FE, Kupfer DJ, editors Psychopharmacology: The fourth generation of progress. New
York; Raven Press 1995: 295-302
- 19
Shiloh R, Zemishlany Z, Aizenberg D, Radwan M, Schwartz B, Dorfman-Etrog P, Modai I,
Khaikin M, Weizman A.
Sulpiride augmentation in people with schizophrenia partially responsive to clozapine.
A double-blind, placebo-controlled study.
Br J Psychiatry.
1995;
171
569-573
- 20
Tokunaga H, Kudo K, Imamura T, Jitsufuchi N, Ohtsuka Y, Ikeda N.
Plasma concentrations of antipsychotic drugs in psychiatric inpatients.
Nippon Hoigaku Zasshi.
1997;
51
417-422
- 21
Tokunaga H, Kudo K, Jitsufuchi N, Ohtsuka Y, Imamura T.
Sensitive determination of sulpiride in human plasma by high-performance liquid chromatography.
J Chromatogr B Biomed Sci Appl.
1997;
691
203-207
- 22
Vergoni A V, Forgione A, Bertolini A.
Chronic administration of l-sulpiride at non-neuroleptic doses reduces the duration
of immobility on experimental models of “depression-like” behavior.
Psychopharmacology.
1995;
121
279-281
- 23
Willner P.
The mesolimbic dopamine system as a target for rapid antidepressant action.
Int Clin Psychopharmacol.
1997;
12
(Suppl 3)
S7-S14
1 Preliminary results of the present paper were presented at the XI. Congress of the
World Psychiatric Association, September 1999, Hamburg, Germany
Dr. Matthias J. Müller
Department of Psychiatry
University of Mainz
Untere Zahlbacher Straße 8
55131 Mainz
Germany
Telefon: ++49-17-2920
Fax: ++49-17-6690
eMail: mjm@mail.psychiatrie.klinik.uni-mainz.de