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Hamostaseologie 1994; 14(03): 133-139
DOI: 10.1055/s-0038-1660356
DOI: 10.1055/s-0038-1660356
Labordiagnostik/Laboratory Diagnostics
Ein einfacher Test für die Bestimmung der Funktion des Von-Willebrand-Faktors: die Kollagenbindungsaktivität
Further Information
Publication History
Publication Date:
26 June 2018 (online)
Zusammenfassung
Die Bindung des Von-Willebrand-Faktors (vWF) an immobilisiertes Kollagen ist die Grundlage eines ELISAs, mit dem die Kollagenbindungsaktivität (vWF:CBA), ein funktioneller Parameter des vWF, bestimmt wird. Dieser Test ist so aufgebaut, daß dieselben Probenverdünnungen, Puffer und Instrumente wie bei dem ELISA für das vWF-Antigen (vWF:Ag) benutzt werden können. Damit ist es möglich, Patienten mit einem Morbus von Willebrand-Jürgens (MWJ) in die Typen I und II zu unterteilen. Der ELISA für die vWF : CBA ist sensitiv, schnell und einfach und kann mit standardisierter ELISA-Ausrüstung und minimaler Plasmamenge ausgeführt werden.
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