Der Einfluss der Sexualhormone auf die Gefäßbiologie der Venen^[*]

Zusammenfassung

Die wichtigsten Erkrankungen der Venen stellen Varikose, Thrombose und Phlebosklerose, in diesem Artikel als chronisch-venöse Erkrankung (CVE) bezeichnet, dar. Es ist unklar, wie Varikose entsteht. Die Forschung der letzten Jahre hat gezeigt, dass Gefäßerkrankungen die Folge von Gefäßwandumbauvorgängen darstellen. Diese werden von molekularen Mechanismen gesteuert. Da das Auftreten von Varikose klinisch mit Schwangerschaft und Hormonapplikation koinzidiert, beschäftigt sich der folgende Artikel mit den Wirkungen von Sexualhormonen auf bekannte Proteine, die das Gefäßremodeling steuern. Derzeit sind die Schlüsselmechanismen des vaskulären Remodelings der Venen noch nicht ausreichend erforscht, um eine direkte Umsetzung in die praktische Medizin zu rechtfertigen.

Summary

Varicosis, thrombosis and phlebosclerosis represent the spectrum of chronic venous disease. The mechanisms underlying varicosis are unknown. Recent data suggest that vascular disease results from transmural remodeling processes, that are triggered by molecular events. Because varicosis is clinically related to pregnancy and hormone treatment, this manuscript deals with the effects of sex steroids on proteins that are controlling vascular remodeling. Key mechanisms of vascular remodeling of veins are not sufficiently known to justify therapeutic recommendations.

Résumé

Les plus importantes pathologies veineuses sont la varicose, les thromboses et la sclerose des veines, ainsi les maladies veineuses chroniques. Le developpement de la varicose n’est pas éclairé. Les études sciéntifiques recentes ont montrées que les maladies veineuses sont les sequelles du remodeling des vaisseaux. Lequel est dirigé par des mechanismes moleculaires. Car l’ incidence des varicoses est lié avec la grossesse et l’application des hormones, cet article trait l’effet des hormones sur divers proteines, qui réglementent le fonctionnement des vaisseaux. Les points cléfs du fonctionnement du remodeling des vaissaux ne sont pas encore assez étudiés, qu’on puisse présenter des recommendations thérapeutiques par traitement hormonel.

La biologie veineuse sous l’influence des hormones

Schlüsselwörter

Östrogen - Progesteron - chronisch-venöse Insuffizienz

Keywords

Estrogen - progesterone - chronic venous insufficiency

Mots clés

Oestrogènes - gestagènes - insuffisance veineuse chronique

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