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CC BY ND NC 4.0 · SynOpen 2019; 03(01): 26-35
DOI: 10.1055/s-0037-1611665
DOI: 10.1055/s-0037-1611665
paper
Stereoselective Total Synthesis of Macrolide Sch-725674 and C-7-epi-Sch-725674
K.B. and A.T. are grateful to CSIR-New Delhi and UGC-New Delhi, respectively, for providing Fellowships, and the Minister of Science and Technology for providing financial support under DST-SERB-GAP-0563.
Further Information
Publication History
Received: 12 December 2018
Accepted after revision: 09 January 2019
Publication Date:
26 February 2019 (online)
Abstract
The stereoselective total synthesis of Sch-725674 in 14 linear synthetic steps with 10.3% overall yield is described. The synthesis started from commercially available starting materials, d-ribose and (R)-benzyl glycidol. The key reactions involved CBS reduction, Julia–Kocienski olefination, Horner–Wadsworth–Emmons reaction, and Shiina macrolactonization.
Keywords
natural product synthesis - macrolides - Sch-725674 - C-7-epi-Sch-725674 - antifungal agentsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611665.
- Supporting Information
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