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Synfacts 2008(7): 0746-0746
DOI: 10.1055/s-2008-1077830
DOI: 10.1055/s-2008-1077830
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Isoquinolone Synthesis via Decarbonylative Addition of Phthalimides to Alkynes
Y. Kajita, S. Matsubara*, T. Kurahashi*
Kyoto University, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. Juni 2008 (online)
Significance
A novel synthetic access to isoquinolones via a Ni(0)-catalyzed decarbonylative addition of alkynes to phthalimides has been developed. This reaction shows that activated C-N bonds can undergo a decarbonylative Ni(0)-complex insertion enabling an intermolecular addition to alkynes.