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Horm Metab Res 2007; 39(5): 341-346
DOI: 10.1055/s-2007-976541
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© Georg Thieme Verlag KG Stuttgart · New York

Insulin Sensitivity and β-Cell Function in Healthy Cats: Assessment with the Use of the Hyperglycemic Glucose Clamp

L. I. Slingerland 1 , J. H. Robben 1 , T. W. van Haeften 2 , H. S. Kooistra 1 , A. Rijnberk 1
  • 1Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
  • 2Department of Internal Medicine, University Medical Center Utrecht, The Netherlands
Further Information

Publication History

received 16. 10. 2006

accepted 7. 2. 2007

Publication Date:
29 May 2007 (online)

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Abstract

A hyperglycemic clamp (HGC) was developed for use in conscious cats. In 21 healthy, normal glucose tolerant cats glucose disposal rate (M), insulin sensitivity (ISIHGC), and β-cell response (I) at arterial plasma glucose of 9 mmol·l-1 were measured. The HGC was tolerated well and steady state glucose infusion was achieved. Compared to values reported for humans, M values for the cats were low, which appeared to relate to both a low ISIHGC and a low I. HGC measures correlated with fasting plasma glucose and insulin concentrations as well as with their HOMA (homeostasis model assessment) and QUICKI (quantitative insulin sensitivity check index) counterparts. Also, I and ISIHGC correlated with their counterparts derived from intravenous glucose tolerance tests. In conclusion, this is the first report of hyperglycemic glucose clamping in cats. The procedure (HGC) allows for measurements of glucose disposal, β-cell response and insulin sensitivity. Compared to human data, both insulin sensitivity and insulin secretion appeared to be low in cats. This is compatible with the carnivorous nature of this species, for which insulin resistance would be advantageous during periods of restricted food availability.

Key words

diabetes mellitus - glucose tolerance test - HOMA - QUICKI - carnivore connection theory

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Correspondence

L. I. Slingerland

Department of Clinical Sciences of Companion Animals

Faculty of Veterinary Medicine

Utrecht University

Yalelaan 108

3584 CM Utrecht

The Netherlands

Phone: +31/30/253 16 83

Fax: +31/30/251 81 26

Email: l.i.slingerland@vet.uu.nl

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