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Horm Metab Res 2007; 39(4): 278-281
DOI: 10.1055/s-2007-973813
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Different Uptake and Handling of Oleoyl-estrone by Fetuses and Neonatal Rats

B. García-Peláez 1 , R. Vilà 1 , X. Remesar 1
  • 1Departament de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Further Information

Publication History

received 7. 9. 2006

accepted 9. 11. 2006

Publication Date:
19 April 2007 (online)

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Abstract

To determine whether oleoyl-estrone can be transferred from mothers to their offspring either during pregnancy or lactation, a gavage of tracer dose of 3H-Oleoyl-estrone was given to 21-day pregnant rats and to lactating rats on day 15 after delivery. In pregnant rats, the label was found in maternal blood as well as in liver and fetal serum, the latter showing the highest specific activity observed. In lactating rats, oleoyl-estrone label was found both in the mammary gland and maternal serum; in the pups, label was found in their stomach contents (i.e., clotted milk) and serum. The results suggest that the placenta effectively blocks the passage of oleoyl-estrone to the fetuses probably because of its high esterase activity. On the other hand, oleoyl-estrone is easily transferred from dams to pups, as a component of milk.

Key words

oleoyl-estrone treatment - lactating dams - pregnant rats

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Correspondence

Prof. X. Remesar

Departament de Nutrició i Bromatologia

Facultat de Biologia

Universitat de Barcelona

Av. Diagonal 645

08028 Barcelona

Phone: +34/93/402 15 18

Fax: +34/93/403 70 64

Email: xremesar@ub.edu