Contraceptive and Hormonal Properties of Achyranthes aspera in Rats and Hamsters1

Vinita Wadhwa; M. M. Singh; D. N. Gupta; Chandan Singh; V. P. Kamboj

doi:10.1055/s-2007-969131

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Planta Med 1986; 52(3): 231-233
DOI: 10.1055/s-2007-969131

Communications

Contraceptive and Hormonal Properties of Achyranthes aspera in Rats and Hamsters¹

Vinita Wadhwa² , M. M. Singh² , D. N. Gupta² , Chandan Singh³ , V. P. Kamboj²

²Division of Endocrinology, Central Drug Research Institute, Lucknow - 226 001. India.
³Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow - 226 001, India.

1 Communication No. 3708.

Weitere Informationen

Publikationsverlauf

1985

Publikationsdatum:
26. Februar 2007 (online)

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Abstract

n-Butanol fraction of aerial parts of Achyranthes aspera Linn. prevented pregnancy in adult female rats when administered orally at 75 mg/kg dose on days 1-5 post-coitum, but was ineffective in hamsters upto 300 mg/kg dose. In ovariectomized immature female rats, the extract exhibited potent estrogenic activity at the contraceptive dose but was devoid of any antiestrogenic activity. 100% uterine weight gain was achieved at 1/15th of the contraceptive dose. Significant uterotrophic effect was discerned even at 1/20th of the contraceptive dose. Taking 100% increase in uterine weight as the parameter, estrogenic activity of the extract was found to be 1/2750 that of ethynylestradiol.

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