Chemical Study on Alkaloids from Corydalis bulleyana

Abstract

Twenty three isoquinoline-type alkaloids were isolated from whole plant of Corydalis bulleyana Diels. Sixteen of them were identified as known alkaloids, namely, protopine (1), (+)consperine (2), (+)acetylcorynoline (3), dihydrosangunarine (4), (+)acetylisocorynoline (6), (±)stylopine (7), (+)corynoline (8), (+)corynoloxine (9, (+)isocorynoline (10), (-)chelanthifoline (13), corycavamine (14), (+)scoulerine (15), (+)isoboldine (16), acetylcorydamine (18), allocryptopine (21) and corydamine (23). The remainder were new alkaloids and were referred to as bulleyanine [(6-acetonylacetylisocorynoline)] (5), (+)6-acetonylcorynoline (11), (+)12-formyloxycorynoline (12), (+)6-oxoacetylcorynoline (17), (+)12-hydroxycorynoline (19), (+)bulleyanaline [(+)6-acetonyl-12-hydroxycorynoline] (20) and (+)norjuziphine (22), respectively. Their structures have been elucidated by means of spectral and chemical methods.