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Planta Med 1986; 52(3): 171-175
DOI: 10.1055/s-2007-969113
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© Georg Thieme Verlag Stuttgart · New York

Effect of Oriental Plant Drugs on Platelet Aggregation; III1. Effect of Chines Drug “Xiebai” on Human Platelet Aggregation

T. Okuyama2 , S. Shibata2 , M. Hoson3 , T. Kawada3 , H. Osada3 , T. Noguchi3
  • 2Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Nozawa 1-35-23, Setagaya-ku, Tokyo, Japan.
  • 3The Third Department of Surgery, St. Marianna University School of Medicine, Sugao 2095, Miyamae-ku, Kawasaki-shi, Japan.
1 Part II of this series: Okuyma, T., Kawasaki, C., Shibata, S., Hoson, M., Kawada, T., Osada, H., Noguchi, T. (1986) Planta Med. 132.
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1985

Publikationsdatum:
26. Februar 2007 (online)

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Abstract

The effect of the Chinese crude drug “Xiebai” and its components on human platelet aggregation induced by 2 µM ADP was studied. From the ethyl acetate-soluble fraction giving a remarkable inhibitory effect against platelet aggregation, N-p-coumaroyltyramine (1) and N-trans-feruloyl tyramine (2) were isolated as the active principles. Compound 2 showed a strong inhibitory activity against both the primary and secondary wave aggregation induced by 2 µM ADP of human platelet, whereas 1 was effective only against the primary aggregation. In comparison with the above compounds cinnamic acid derivatives (3-6) and tyramine (7) were also examined with respect to human platelet aggregation. Compounds 3 and 5 showed the inhibitory activity against both the primary and secondary wave aggregation as did as 2, while 6 inhibited only the primary aggregation, and 4 gave a lower effect. Compound 7 showed inhibition only upon the secondary aggregation.

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