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Synfacts 2007(7): 0678-0678
DOI: 10.1055/s-2007-968601
DOI: 10.1055/s-2007-968601
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of ent-Peribysin E
A. R. Angeles, D. C. Dorn, C. A. Kou, M. A. S. Moore, S. J. Danishefsky*
Sloan-Kettering Institute of Cancer Research, New York, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Juni 2007 (online)
Significance
Peribysin E is a cell adhesion inhibitor isolated from Periconia byssoides OUPS-N133. The first total synthesis of peribysin E is reported which features the ring contraction of epoxide G to aldehyde H. Completion of the synthesis revealed that the wrong absolute configuration had been assigned to the natural product.