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Planta Med 1992; 58(2): 128-130
DOI: 10.1055/s-2006-961413
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© Georg Thieme Verlag Stuttgart · New York

Time Course and Inhibition of Saponin-Induced Hemolysis

Masayuki Takechi1 , Shigetoshi Shimada2 , Yasuo Tanaka1
  • 1Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka 577, Japan
  • 2Shimada Pharmaceutical Institute, 3-16-27, Kohama, Suminoe-ku, Osaka 559, Japan
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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

Hemolytic activities of 3 steroid saponins reached plateaus within 5 min, whereas those of 4 triterpenoid saponins did not within 60 min. Erythrocytes pretreated with a low concentration of tigogenin were resistant to hemolysis of some of these saponins, but those pretreated with hecogenin or tomatidine were as sensitive as non-treated erythrocytes. Therefore, the ketone group of hecogenin or the amino group of tomatidine would weaken the interactions between the erythrocytes and these sapogenins. Furthermore, incubations of these saponins with a small amount of cholesterol diminished the hemolytic activities.

Key words

Hemolysis - time course - inhibition - saponin - sapogenin - cholesterol

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