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Synfacts 2006(12): 1291-1291  
DOI: 10.1055/s-2006-955626
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

SBA-15-Supported Acid-Base Catalyst for Aldol Reaction

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Takayasu Arakawa
R. K. Zeidan, S.-J. Hwang, M. E. Davis*
California Institute of Technology, Pasadena, USA
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Publication History

Publication Date:
22 November 2006 (online)

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Significance

A silica gel (SBA-15)-supported acid/base catalyst 3 for the direct aldol reaction was developed. Thus, catalyst 3 was prepared from 2-(4-chlorosulfonylphenyl)ethyltrimethoxy­silane 1, 3-aminopropyltrimethoxysilane 2, triblock copolymer P123, and tetraethoxysilane (TEOS). The direct aldol reaction of p-nitrobenzaldehyde (0.05 M) with acetone by using catalyst 1 (10 mol%) gave β-hydroxy ketone 4 (75% yield) and α,β-unsaturated ketone 5 (13%).