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Synfacts 2006(12): 1244-1244  
DOI: 10.1055/s-2006-949500
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

New Phosphine-Phosphoramidite Ligands for Hydrogenations

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
J.-D. Huang, X.-P. Hu*, Z.-C. Duan, Q.-H. Zeng, S.-B. Yu, J. Deng, D.-Y. Wang, Z. Zheng*
Dalian Institute of Chemical Physics and Graduate School of Chinese Academy of Sciences, Beijing, P. R. of China
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Publication History

Publication Date:
22 November 2006 (online)

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Significance

A new type of ligand for the rhodium-catalyzed hydrogenation is described. These ligands are air- and moisture-stable, and give high enantioselectivities. The ligand precursor is easily synthesized in two steps and 21% overall yield. This ligand worked very well for the hydrogenation of α-dehydroamino acid esters, enamides, and dimethyl itaconate.