Aryl Trihydroxyborates as Convenient Species for Cross-Coupling Reactions

Significance

The authors decribe novel interesting substituents for the conventional arylboronic acids: aryl trihydroxyborates. They are stable, convenient for handling compounds with exact stoichiometry, and very easy to prepare from the corresponding arylboronic acids. They can be used for generally the same reactions as prototypical boronic acids, often without the need of additional bases. Thus, they are a useful storable alternative to the conventional boronic acids. Aryl, hetaryl and alkyl trihydroxyborates were successfully prepared and their reactivity was demonstrated in the cross-coupling and in Rh-catalyzed 1,4-addition reactions.