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Synfacts 2006(8): 0747-0747  
DOI: 10.1055/s-2006-941933
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Dolabelide D

Contributor(s): Philip Kocienski, John Cooksey
P. K. Park, S. J. O’Malley, D. R. Schmidt, J. L. Leighton*
Columbia University, New York, USA
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Publication History

Publication Date:
21 July 2006 (online)

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Significance

Dolabelide D is a cytotoxic 24-membered macrolide isolated from the sea hare Dolabella auricularia. The Leighton group reports the first total synthesis of Dolabelide D making extensive use of their catalytic asymmetric silane alcoholysis and Rh-catalyzed tandem silylformylation/crotylsilylation reactions.