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Planta Med 2001; 67(5): 423-427
DOI: 10.1055/s-2001-15820
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

A New Tetrahydroprotoberberine N-Oxide Alkaloid and Anti-Platelet Aggregation Constituents of Corydalis tashiroi

Jih-Jung Chen1 , Ya-Ling Chang2 , Che-Ming Teng2 , Wei-Yu Lin3 , Yu-Chang Chen3 , Ih-Sheng Chen3,*
  • 1 Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China
  • 2 Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
  • 3 Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
Further Information

Publication History

July 28, 2000

December 2, 2000

Publication Date:
31 December 2001 (online)

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Abstract

A new tetrahydroprotoberberine N-oxide alkaloid, (-)-cis-isocorypalmine N-oxide (1), together with two known compounds, 6-methoxydihydrosanguinarine (2) and norjuziphine (3), were isolated in continuing studies of the entire Formosan Corydalis tashiroi plant. The structures of these three compounds were determined through spectral analyses. In addition, compounds 1, 2, 3 and the seven alkaloids previously reported: (-)-cis-corydalmine N-oxide, (-)-trans-corydalmine N-oxide, (-)-trans-isocorypalmine N-oxide, scoulerine, protopine, oxysanguinarine and corydalmine, were found to possess anti-platelet aggregation activity.

Key words

Corydalis tashiroi - Fumariaceae - alkaloids - berberine - tetrahydroprotoberberine N-oxide - (-)-cis-isocorypalmine N-oxide - anti-platelet aggregation activity

References

  • 1 Liu T S, Yang K C. Fumariaceae in Flora of Taiwan. 2nd edition. Editorial Committee of the Flora of Taiwan Taipei, Taiwan.; 1996; Vol. 2: 726-33
  • 2 Lu S T, Lin C N, Wu T S. Studies on the alkaloids of Formosan Corydalis species. Part III. Alkaloids of Corydalis tashiroi Makino.  J. Chin. Chem. Soc.. 1972;  19 41-4
    PubMedGoogle Scholar
  • 3 Tani C, Nagakura N, Saeki S, Kao M T. Alkaloids of papaveraceous plants. XXXIV. Alkaloids of Corydalis tashiroi .  Planta Medica. 1981;  41 403-5
    PubMedGoogle Scholar
  • 4 Chen J J, Duh C Y, Chen I S. New tetrahydroprotoberberine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi .  Planta Medica. 1999;  65 643-7
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Teng C M, Chen W Y, Ko W C, Ouyang C. Antiplatelet effect of butylidenephthalide.  Biochem. Biophys. Acta. 1987;  924 375-82
    PubMedGoogle Scholar
  • 6 O'Brien J R. Platelet aggregation II. Some results from a new method of study.  J. Clin. Path.. 1962;  15 452-5
    PubMedGoogle Scholar
  • 7 Pandey V B, Ray A B, Dasgupta B. Minor alkaloids of Fumaria indica seeds.  Phytochemistry. 1979;  18 695-6
    CrossrefPubMedGoogle Scholar
  • 8 El-Kawi M A, Slatkin D J, Schiff Jr. P L, Dasgupta S, Chattopadhyay S K, Ray A B. Additional alkaloids of Pachygone ovata .  J. Nat. Prod.. 1984;  47 459-64
    CrossrefPubMedGoogle Scholar
  • 9 Vane J R. Inhibition of prostaglandin biosynthesis as a mechanism of action for aspirin-like drugs.  Nature (New Biology). 1971;  231 232-5
    PubMedGoogle Scholar

Prof. Dr I. S. Chen

Graduate Institute of

Pharmaceutical Sciences

Kaohsiung Medical University

Kaohsiung

Taiwan

Republic of China

Email: m635013@cc.kmu.edu.tw

Fax: +886-7-3210683

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