Triterpenoid Saponins from Clematis tangutica

Abstract

Two new triterpenoid saponins, tanguticoside A and B along with seven known saponins vitalboside B, α-hederin, saponin PK, β-hederin, saponin PJ₃, saponin PE, and ciwujianoside A were isolated from aerial part of Clematis tangutica. By chemical and spectral evidences methods, the structures of tanguticoside A and B were elucidated as 3-O-β-D-glucopyranosylhederagenin 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside and 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosylhederagenin 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside, respectively.

References

• 1 Northwest Plateau Institute of Biology,. Academia Sinica. “Zang Yao Zhi”. Xining; Qinhai People's Press 1991: 249
• 2 Tori K, Seo S, Shimaoka A, Tomita Y. Carbon-13 NMR spectra of olean-12-ene. Full signal assignments including quaternary carbon signals assigned by use of indirect ¹³C - ¹H spin couplings.  Tetrahedron Letters. 1974;  4227-30
• 3 Hostettmann K. Saponins with molluscicidal activity from Hedera helix L.  Helvetica Chemica Acta. 1980;  63 606-9
• 4 Aoki T, Tanio Y, Suga T. Triterpenoid saponins from Fatsia japonica .  Phytochemistry. 1976;  15 781-4
• 5 Chirva V Y, Kintya P K, Melnikov V N. New data on triterpene glycosides. In: Rozinskaya VN, editor Dokl. Soobshch.-Mendeleevsk. S'ezd Obsch. Prikl. Chim 11th. Moscow; “Nauka” 1975: 6, 109
• 6 Ryuichi H, Toshio K. Pericap saponins of Akedia quinata Decne I. Glycosides of hederagenin and oleanolic acid.  Chemical and Pharmaceutical Bulletin. 1976;  24 1021-32
• 7 Shao C J, Kasai R, Xu J D, Tanaka O, Ciwujia I I. Structures of ciwujianosides A₁, A₂, A₃, A₄ and D₃ .  Chemical and Pharmaceutical Bulletin. 1989;  37 42-5