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Thromb Haemost 1980; 44(02): 062-064
DOI: 10.1055/s-0038-1650084
Original Article
Schattauer GmbH Stuttgart

In Vitro Inhibition of Platelet Aggregation by Bile Salts

G Baele
The Department of Medicine and the Coagulation Laboratory, Academisch Ziekenhuis, University of Ghent, Ghent, Belgium
,
R Beke
The Department of Medicine and the Coagulation Laboratory, Academisch Ziekenhuis, University of Ghent, Ghent, Belgium
,
F Barbier
The Department of Medicine and the Coagulation Laboratory, Academisch Ziekenhuis, University of Ghent, Ghent, Belgium
› Author Affiliations
Further Information

Publication History

Received 24 December 1979

Accepted 30 July 1980

Publication Date:
13 July 2018 (online)

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Summary

In a series of in vitro experiments, the influence of bile salts on platelet aggregation by ADP or by collagen and on serotonin-14C release by collagen, was studied.

Sodium salts of the following bile acids showed a clear inhibitory effect: glycochenodeoxycholic acid, taurochenodeoxycholic acid, glycocholic acid, taurocholic acid and cholic acid. Lowering the pH of the platelet-rich plasma resulted in decreased platelet aggregation by ADP and by collagen. Bile salts further enhanced the inhibitory effect of pH change. In contrast the sodium salt of chenodeoxycholic acid was the sole aggregation inducing bile salt we studied. Relating the above studies to the clinical situation of upper gastroduodenal mucosal haemorrhage, we suggest that biliary reflux as well as the acidic environment may contribute to a poor haemostatic response by impaired platelet aggregation in the upper gastrointestinal tract of otherwise normal human subjects.

Key words

Platelet(s) - Platelet-Aggregation - Bile - Bile-Acid(s) - Bile-Salt(s)
 

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