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Semin Thromb Hemost 2016; 42(01): 075-086
DOI: 10.1055/s-0035-1564843
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Correlation between ABO Blood Group, and Conventional Hematological and Metabolic Parameters in Blood Donors

Massimo Franchini
1   Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy
,
Carlo Mengoli
2   University of Padova, Padova, Italy
,
Enrico Capuzzo
1   Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy
,
Isabella Terenziani
3   Laboratory, Carlo Poma Hospital, Mantova, Italy
,
Carlo Bonfanti
1   Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy
,
Giuseppe Lippi
4   Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
23 November 2015 (online)

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Abstract

Background Although several studies have investigated and confirmed the existence of an association between ABO blood type and several human disorders, especially with cardiovascular disease, little is known on the physiological influence or association of ABO blood groups on basal levels of some conventional hematological and metabolic parameters.

Study Design and Methods A total number of 7,723 consecutive healthy blood donors underwent laboratory testing at the time of their first blood donation, which apart from ABO typing included assessment of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, total bilirubin, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides, creatinine, iron, ferritin, uric acid, glucose, hemoglobin, and platelet count.

Results The most relevant finding was the identification of significantly higher values of total cholesterol and HDL-c in subjects with blood group A compared with those with O blood type, with the highest levels being observed in A1 subtype.

Conclusions The positive association between A blood type and plasma lipid levels supports its potential role in the pathogenesis of atherosclerosis and the clinical observations of increased vulnerability to cardiovascular disease of individuals with non-O blood groups.

Keywords

ABO blood groups - cholesterol - plasma lipids - cardiovascular disease - thrombosis
 

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