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Planta Med 2016; 82(05): 414-417
DOI: 10.1055/s-0035-1558331
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Antiviral and Cytotoxic Isocoumarin Derivatives from an Endophytic Fungus Aspergillus oryzae

Min Zhou
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China
2   School of Ethnic Medicine, Yunnan Minzu University, Kunming, P. R. China
3   Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming, P. R. China
,
Kun Zhou
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China
2   School of Ethnic Medicine, Yunnan Minzu University, Kunming, P. R. China
,
Pei He
3   Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming, P. R. China
,
Kun-Miao Wang
3   Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming, P. R. China
,
Rui-Zhi Zhu
3   Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming, P. R. China
,
Yue-De Wang
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China
2   School of Ethnic Medicine, Yunnan Minzu University, Kunming, P. R. China
,
Wei Dong
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China
2   School of Ethnic Medicine, Yunnan Minzu University, Kunming, P. R. China
,
Gan-Peng Li
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China
2   School of Ethnic Medicine, Yunnan Minzu University, Kunming, P. R. China
,
Hai-Ying Yang
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China
,
Yan-Qing Ye
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China
,
Gang Du
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China
2   School of Ethnic Medicine, Yunnan Minzu University, Kunming, P. R. China
,
Xue-Mei Li
3   Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming, P. R. China
,
Qiu-Fen Hu
1   Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P. R. China
2   School of Ethnic Medicine, Yunnan Minzu University, Kunming, P. R. China
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Publikationsverlauf

received 14. September 2015
revised 03. November 2015

accepted 09. November 2015

Publikationsdatum:
29. Januar 2016 (online)

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Abstract

Oryzaeins A–D (1-4), four new isocoumarin derivatives, along with five known ones (5-9) were isolated from solid cultures of an endophytic fungus Aspergillus oryzae. Their structures were elucidated by detailed spectroscopic analysis and by comparison with reported data of related derivatives. Among them, compounds 1 and 2 represent the first examples of isocoumarins possessing an unusual 2-oxopropyl group and a rare 3-hydroxypropyl group. Compounds 1 and 2 displayed moderate anti-tobacco mosaic virus activities with inhibition rates of 28.4 % and 30.6 %, respectively, at the concentration of 20 µM. The new compounds showed moderate inhibitory activities against several human tumor cell lines with IC50 values in the range of 2.8–8.8 µM.

Supporting information available online at http://www.thieme-connect.de/products

Key words

Aspergillus oryzae - Trichocomaceae - isocoumarin derivatives - anti-tobacco mosaic virus activity - cytotoxicity

Supporting Information

 

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