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Synfacts 2009(12): 1386-1386  
DOI: 10.1055/s-0029-1218167
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd(II)-Catalyzed Direct Benzylation of Heteroarenes

Contributor(s): Paul Knochel, Andrei Gavryushin
D. Lapointe, K. Fagnou*
University of Ottawa, Canada
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Publikationsdatum:
20. November 2009 (online)

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Significance

A broadly applicable palladium-­catalyzed benzylation of heteroarenes is reported. Especially important is the high reactivity of heterocycles like oxazoles and thiazoles, most challenging for the electrophilic alkylation. The reaction is highly regioselective and gives rise to industrially important diarylmethane compounds.