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Synfacts 2009(5): 0530-0530
DOI: 10.1055/s-0029-1216587
DOI: 10.1055/s-0029-1216587
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
CoCl2-Catalyzed Reductive Cyclization of Nitro Cyclic Sulfites
A. R. Jagdale, R. S. Reddy, A. Sudalai*
National Chemical Laboratory, Pune, India
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2009 (online)
Significance
A new method for the asymmetric synthesis of tetrahydroquinolin-3-ols is described. The procedure involves a cobalt-catalyzed, one-pot reductive cyclization of nitro cyclic sulfites in the presence of sodium borohydride. The resulting 3-substituted tetrahydroquinoline derivatives are obtained in high yield and enantioselectivity.