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Exp Clin Endocrinol Diabetes 1993; 101(3): 189-193
DOI: 10.1055/s-0029-1211230
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Neonatal Stimulation of β-cells Reduces the Incidence and Delays the Onset of Diabetes in a Barrier-protected Breeding Colony of BB Rats

A. K. Hansen1 , K. Josefsen2 , C. Pedersen2 , K. Buschard2
  • 1Animal Department, Panum Institute, University of Copenhagen
  • 2Bartholin Institute, Kommunehospitalet, Copenhagen
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

The off-spring in a barrier maintained colony of spontaneously type 1 diabetic BB/Wor/Mol-BB rats was treated with a daily injection of either saline, forskolin, arginine, glucose or both glucose and arginine for the first six days after birth. The incidence was reduced from 88% to 72% by the neonatal stimulation with arginine and glucose in combination, which also delayed the onset time from 76.0 ± 2.2 days to 88.1 ± 2.3 days. No such effect was observed after stimulation with either one of the compunds. Neonatal stimulation with forskolin also delayed the onset to 87.9 ± 3.8 days, however without reducing the incidence. A higher incidence of diabetes was observed in the barrier-protected rats taking part in this study than in an earlier study using BB rats of the same origin, but kept under conventional conditions.

Key words

BB rat - Rattus norwegicus - Diabetes mellitus - Neonatal stimulation - β-cells

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