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Exp Clin Endocrinol Diabetes 1989; 93(2/03): 208-212
DOI: 10.1055/s-0029-1210858
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Effect of Cyclosporin A on the Endocrine Pancreas of Rats

Regina Jablenska
  • Department of Anatomy and Histology, Medical Academy, Sofia, Bulgaria
Further Information

Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

Treatment with the immunosuppressive agent Cyclosporin A frequently gives rise to alteration of function in the Langerhans islet which may result in diabetes.

Light microscopy, immunocytochemical, and electron microscopic investigations demonstrate degranulation and vacuolization of B endocrine pancreatic cells in treated animals. Similar changes, but to a milder degree, are observed in the A-cells. The morphological alterations described are likely to result from an inhibition of the synthesis and secretion of B-cells.

Key Words

Morphology - Rat - A-cell - B-cell

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