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DOI: 10.1055/s-0029-1210678
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
The Modulating Effect of Estrogens on Luteinizing Hormone Release in complete Androgen Insensitivity Syndrome before and after Gonadectomy and Cyclic Steroid Application
Publication History
1986
Publication Date:
16 July 2009 (online)
Summary
The response of LH release to exogenous estrogens was studied in three patients with androgen insensitivity syndrome (AIS) before and after gonadectomy and a prolonged treatment with a sequential pill.
Estrogen provocation tests were performed in which 0.05 mg/kg body weight estradiol benzoate was administered intramuscularly and serum FSH and LH levels were assessed every 12 hours for 96 hours after gonadectomy, three months after a prolonged treatment with a sequential pill (16 cycles: 9 days mestranol 100 μg, 12 days mestranol 80 μg and chlormadinone acetate 2 mg) and in one patient before gonadectomy.
The control group consisted of 10 normal females during the follicular phase. A positive feedback effect was induced in normal females and in AIS patients after prolonged treatment with a sequential pill.
Key words
Androgen Insensitivity Syndrome - Gonadectomy - LH release - Exogenous estrogens - Positive feed back