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Exp Clin Endocrinol Diabetes 1987; 89(3): 297-300
DOI: 10.1055/s-0029-1210653
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Insulin-Dependent Diabetes: Strategy for Immune Intervention

Monique Debbay-Sachs, G. Feutren, C. Boitard, R. Assan, J. F. Bach
  • Hôpital Necker, Paris/France
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Publication History

1986

Publication Date:
16 July 2009 (online)

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Summary

Increasingly, experimental results are underlining the role played by autoimmune mechanisms in the pathogenesis of type I insulin-dependent diabetes mellitus (IDDM). It has appeared logical to attempt to preclude the onset of IDDM by suppressing immune responses, but trials using steroids or azathioprine were unequivocal. Subsequently, a Canadian and a French group performed pilot studies to assay a new immunosuppressive drug, cyclosporine A (CyA) in human diabetes (Stiller et al., 1984; Assan et al., 1985). However, further testing is required to evaluate and confirm its potential benefits and possible risks.

Key words

Diabetes - Immunosuppression - Cyclosporine A

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